Primitive Stem Cells Could Be Used For Complicated Bone Fractures – Texas A&M University Today


A close-up view of the intricate microarchitecture of the pluripotent stem-cell-derived extracellular matrix.

A close-up view of the intricate microarchitecture of the pluripotent stem-cell-derived extracellular matrix.


Courtesy of Carl Gregory

Although most broken bones can be mended with a firm cast, more complicated fractures require treatments like bone grafting. Researchers at Texas A&M University have now created superior bone grafts using primitive stem cells. They found that these cells help create the fertile scaffolds needed for the bone to regenerate at the site of repair.

The researchers said these grafts could be used to promote swift and precise bone healing so that patients maximally benefit from the surgical intervention.

“There are several problems that can occur with orthopedic implants, like inflammation and pain. Also, they can loosen, requiring revision surgeries that are often more complicated than the original surgery to put in the implant,” Roland Kaunas, associate professor in the Department of Biomedical Engineering and a corresponding author on the study. “So, by speeding up the bone healing process, our material can potentially reduce the number of these revision surgeries.”

The researchers have published their findings in the June issue of the journal Nature Communications.

Each year, around 600,000 people in the United States experience delayed or incomplete bone healing. For some of these cases, physicians turn to surgical procedures that involve transplanting bone tissue to the repair site. These bone grafts
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