Heart regeneration using stem cells: Why irregular heartbeats occur after transplantation – EurekAlert


IMAGE: The researchers observed several electric parameters such as the beating rate. The nodal-like cells beat a little faster than the working-type cells. The dV/dt acts like the starting software. The… view more 

Credit: Copyright © 2020, Springer Nature

Stem cells are heavily studied around the world with the hope to revive damaged body parts unable to regenerate itself. Injured heart muscles are one of these areas which remain impaired in adults who have experienced heart attacks. Once a part of a heart tissue is injured due to restricted blood flow during a heart attack, treatment options are dire to fix the function of the heart to previous capacity. Stem cells are promising because they can be manipulated to generate healthy cells to replace diseased cells. No other cells hold this promise. There are a few issues to clear before stem cell treatments can be implemented clinically for heart regeneration and one major obstacle is to understand why irregular, abnormal heartbeats occur two to four weeks after iPS cell-derived heart muscle cells are transplanted to the heart. The heartbeat stabilizes on its own after 12 weeks but researchers set out to find out why the arrhythmia occurs.

A team led by Hajime Ichimura of Shinshu University thought